Novel Microscope Offers Super-Resolution Viewing

Researchers highlighted that an EU-supported project is presently engaged in creating a high-resolution microscope. The specialty of this microscope is its size: it is supposed to be so small that it can easily fit on to a computer chip. This microscope can be employed to observe changes in living cells in real time. Probable applications of this microscope include a broad range of science and research sectors, as well as consumer goods, with the innovation capability to fortify European industry.

The resolution achievable with the regular optical microscopes is limited due to the physical laws ruling the wavelength of light. This highlights that they cannot be employed to directly see DNA molecules, single proteins, or inside living cells. At present, only indirect observation is possible with electron microscopes, which are expensive, difficult, and huge. But, such devices are not appropriate for observing subtle living tissues. To deal with these restrictions, the EU-supported CHIPSCOPE project is creating a chip-sized microscope.

On a similar note, a first-of-its-type data analysis platform is allowing scientists to choose the superlative tool for the interpretation of the huge data produced by single-cell research. Precisely making sense of these datasets will assist to explicate the fundamental and diverse roles cells carry out in health and disease. The more details on the latest platform named CellBench can be accessed in the journal Nature Methods.

The open for access platform, which incorporates software and a few gold standard datasets, can compare the performance of numerous diverse single-cell analysis alternatives. This platform enables researchers to spot the best technique for the issues they wish to answer. This project was headed by Mr. Luyi Tian and Matthew Ritchie, Associate Professors, WEHI. Mr. Al J Abadi and Dr. Kim-Anh Lê Cao from the University of Melbourne also participated in this research.

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